منابع مشابه
PPARγ and Proline Oxidase in Cancer
Proline is metabolized by its own specialized enzymes with their own tissue and subcellular localizations and mechanisms of regulation. The central enzyme in this metabolic system is proline oxidase, a flavin adenine dinucleotide-containing enzyme which is tightly bound to mitochondrial inner membranes. The electrons from proline can be used to generate ATP or can directly reduce oxygen to form...
متن کاملMnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.
Proline oxidase (POX), localized on inner mitochondrial membranes, is encoded by a p53-induced gene and metabolically participates in p53-induced apoptosis. Previously, we showed that POX catalyzed the generation of reactive oxygen species (ROS). We and others have demonstrated that overexpression of POX, independent of p53, causes apoptotic cell death in a variety of cancer cells. But a necess...
متن کاملRole of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress.
Flavoproteins catalyze a variety of reactions utilizing flavin mononucleotide or flavin adenine dinucleotide as cofactors. The oxidoreductase properties of flavoenzymes implicate them in redox homeostasis, oxidative stress, and various cellular processes, including programmed cell death. Here we explore three critical flavoproteins involved in apoptosis and redox signaling, ie, apoptosis-induci...
متن کاملLocalisation of proline oxidase and Delta-pyrroline-5-carboxylic acid dehydrogenase in rat liver.
The enzymes of prolinsglutamate oxidation and the preparation of their substrates have been described by Strecker and coworkers. [ 1,3] . The presence of proline oxidase in rat liver mitochondria was described by Johnson and Strecker [2]. A rough localisation of proline oxidase and A-pyrroline&carboxylic acid dehydrogenase in locust flight muscle has been attempted by Brosemer and Veerabhadrapp...
متن کاملBiocatalysts in Cancer Tissue III. Succinic Dehydrogenase and Cytochrome Oxidase*
The accumulation of lactic acid in tumor tissue (15) suggests an inadequacy in the oxidative mechanism. A deficiency of one of the components of the oxidative mechanism, cytochrome c, was demonstrated in the first paper of this series (6). The present article reports the decreased activities of succinic dehydrogenase and of cytochrome oxidase in tumor tissues. These enzymes together with cytoch...
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ژورنال
عنوان ژورنال: BioFactors
سال: 2012
ISSN: 0951-6433
DOI: 10.1002/biof.1036